Contrary to popular belief, prostatitis identified and confirmed by laboratory tests is only about 9%.However, inflammation of the prostate is often repeated or chronic.
The prevalence of chronic forms of prostatitis, characterized by an inactive inflammatory procedure and minor clinical symptoms that reduce quality of life.
In addition to acute and chronic bacterial prostatitis, the chronic inflammatory pelvic pain is separate from each other, in which leukocytes are detected in the third part of the urine or seminal fluid, and chronic pelvic pain without inflammatory changes.
During the occurrence and maintenance of symptoms characteristic of chronic prostatitis, urinary functional disorders, expressed in high urination pressure, in an introstatic reflux that form a turbulent urine flow, the pathogenic effect of microorganisms, immunological reactions and the altered state of pelvic floor muscles are of great importance.
Periodic occurrence and enhancement of the lower urinary tract, sleep disorders and often erectile functions are significantly influenced by the physical and psychological state of the lower urethra (Luts).
The lower urinary tract symptoms of young and middle -aged men are most often caused by the inflammatory process of the prostate gland, but there is always a need for differential diagnosis between adenoma and prostate cancer in terms of age.
There are different reviews on the pathogenesis of chronic prostatitis, which suggests various treatment methods.The treatment of acute prostatitis depends on the identified pathogen and includes primarily antibacterial drugs that have the highest penetration of the prostate tissue.
Acute bacterial prostatitis requires parenteral administration of bacterial antibiotics such as aminoglycosides or third generation cephalosporins.Treatment continues until the fever disappears and the number of blood is normalized.In less severe cases, fluoroquinolones can be prescribed.The duration of treatment with acute prostatitis fluoroquinolones is 2-4 weeks.
In the case of chronic bacterial prostatitis and chronic pelvic pain, treatment is performed with fluoroquinolones or trimetoprim.The patient is then re -examined and antibiotics are continued only when the disease -causing microorganism is known or the patient has a positive effect on therapy.
Chronic prostatitis has a recommended treatment period at least 4-6 weeks.Urodynamic tests showed increased urethral pressure.In this regard, it has been noted that combined treatment with α-blockers and antibiotics is more effective than monotherapy of antibiotic in the inflammatory syndrome of chronic pelvic pain.When prescribing therapy, the doctor should discuss the duration of the patient, the likelihood of side effects, and the need to monitor the efficiency and safety of treatment.
Herbal medicines in the treatment of chronic prostatitis
The use of herbal preparations in the treatment of prostate diseases has a long history.The evidence of herbal efficiency and safety was obtained empirically.
Currently, the possibility of using herbs should be determined by modern ideas for pathogenesis and development of pathological processes, especially in the prostate gland.
Processes such as functional obstruction, turbulence in the prostate urethra, pathological effects of commensal microorganisms, immune changes, disrupt normal metabolism.Some violations are inevitably leading to others.For example, chronic inflammation leads to malfunctions and damage.
Usually, the body consists of non -complete oxidation, the so -called free radicals, which increase in various abnormal conditions, especially during inflammation.The disorder of oxygen supply in which the accumulation rate of active radical compounds (oxygen, nitrogen and chlorine radicals) exceeds the rate of neutralization is called oxidative stress.As a result, oxidative stress causes tissue damage over time, including prostate gland.
Biochemists have long been aware of natural antioxidants: E, C and carotenoids, but they cannot seriously affect oxidative stress.In recent years, more and more attention has been paid to bioflavonoids, which are tens of times stronger in antioxidant activity than vitamin E, vitamin C and beta-carotene.In total, more than 6,000 bioflavonoids are known, of which more than 3,000 flavons and more than 700 isoflavones.All organic coal produced by photosynthesis is approx.2% of the plants are synthesized into flavonoids or other polyphenols.
Flavonoids protect plants from radiation, ultraviolet irradiation, oxidation, diseases, infections, bacteria.One of the herbs containing bioflavonoids is Hedysarum Narlectum, a perennial herbaceous plant from the legumes.This small plant, 25-50 cm high, flourishes with small purple-violet flowers from June to August.
The forgotten Pennyweed roots contain flavonoid quercetin, saponins and other biologically active substances.Chvercetin derivatives have antioxidant activity and are effective in patients with chronic prostatitis, which are confirmed by the results of clinical trials.
In addition to these properties, the catechins in the roots of forgotten Kopeck have high vitamin Activity, strengthen capillary walls and optimize microcirculation.The forgotten Pennyweed roots have adaptogenic properties that also determine the value of the plant's involvement in the complex therapy of patients with chronic prostatitis.
It also contains flavonoids, KNOTWEED (polygonum aviculare), one year of herbaceous weed with small elliptical leaves.A single stem that extends abundantly from the base of the root branches and results in the weight of green shoots.This low -growth plant wore many unnoticed greenish white flowers in May.Knotweed contains a large amount of ascorbic acid, vitamin K and provitamin.
Products based on herbal-Knotweed have long been known in urological practice because of diuretics, antique and adaptogenic effects.The combined use of the audience and KNOTWEED allows us to expect a clinically significant effect.
In clinical practice, the herbs that are made from the audience (root and rhizome) and the KNOTWEED herbal are the tincture of the forgotten audience.
The biologically active substances in tincture contain natural antioxidants and substances that improve microcirculation, which determines the ability of these herbs to reduce the severity of the inflammatory process in the prostate gland and pain syndrome (feeling of pain and difficulty in the perineum, prostatorrhea).
Increased blood circulation of the prostate reduces the severity of lower urinary tract symptoms (including frequent urine, bladder evacuation, weakened urine discharge and a feeling of bladder emptying) and improves the functional state of cave arteries.
Clinical efficiency of tincture from the roots of forgotten kopeck
The efficiency of tincture was tested in an open comparative randomized study.The purpose of the study was the effect of herbal preparations on the dynamics of pain syndrome, objective data and laboratory parameters on the dynamics of patients with chronic prostatitis.
In addition to studying complaints and medical history, the diagnosis has been confirmed by laboratory tests of prostate secretions in the form of pure or urine.Active control in parallel groups has evaluated the effectiveness, safety and tolerability of the drug in patients with chronic prostatitis.
We used the symptomatic index of the National Institute of Health (NIH-CPSI), the analysis of the urinary tract and the comparison of laboratory data to object to the description of the symptoms.In patients, urological diseases, which are accompanied by similar symptoms (benign hyperplasia, prostate cancer), abnormal changes in the nervous system and the gastric intestinal tract.
Prostatitis with periodic aggravations has long adversely affected the emotional and sexual sphere.The observation and changes in erection function were also performed with standard questionnaires in patients with chronic prostatitis.In parallel, the safety of the drug was evaluated compared to other herbal medicines.
In order to clarify the dose of the actual tincture of the forgotten Pennyweed roots, the patients were divided into two groups.The first group, consisting of 30 people, received 1 teaspoon of tincture three times a day.Patients in the second group, which also consisted of 30 people, took the tincture three times a day.
Patient distribution into groups was carried out by a simple randomization method that allowed the study of the effects of the drug in homogeneous groups.The drug red root plus was written on an empty stomach at least 30 minutes before a meal.Before use, the drug was shaken and a single dose was dissolved in 1/3 glasses of water.The duration of treatment was 30 days.
The control group of 20 patients diagnosed in chronic prostatitis received treatment with another herbal preparation during the same period.Efficiency criteria in groups that have taken three times a day, or comparative medicines three times a day, changes in clinical symptoms were based on patients' survey, questionnaire data and urinary diaries.All patients coated have completed the examination.
In the first group, the average age of patients, who have forgotten Kopeck's roots, received three times a day, was 45.5 (37-56) years (median, 25 and 75 percent 25 and 75 percent).In the second group, the average age of patients, who took 2 teaspoons three times a day, was 45.5 (33-55) years.In the control group, the average age of patients was 48 (36-59) years.
There was no statistically significant difference between groups at age (p = 0.63) (analysis of variance with variance analysis).It should be noted that chronic prostatitis has been identified in people of the most active and working age, whose preservation of erection and reproductive functions is particularly important.Of all patients involved in the study, 26 (32.5%) were previously sexually transmitted.The distribution of such patients in the groups was the same.
Prior to prescription Tinkture Plus, 57 (71.3%) patients received the treatment of chronic prostatitis.This was most often antibacterial therapy and/or α-blockers.The distribution of previously treated patients and the type of treatment were not significantly different between groups, which confirms the methods of treatment of pathogenesis and, accordingly, chronic prostatitis.
In order to use the symptoms and their severity, and to use the quality of life of patients, the NIH-CPSI scale was used, which was recommended for both basic assessment and observation of the condition of patients.Initially, the level of pain according to the NIH-CPSI scale was the tincture of the Pennywort roots, three times a day, on the tincture of the Pennywort root, 13 (10-15);In the group that received three (10-15) points a day, the tincture was given on 2 teaspoons.In the control group, this indicator was 13 (10-15) points.There was no statistically significant difference in the severity of the pain between groups (p = 0.846).
Patient groups were homogeneous both in the localization and severity of pain, which is particularly important, given the variety of clinical manifestations of the disease.
Because of the urethral disorders, namely bladder output obstruction, Detrusor-sphincter dyssynergia, prostate urethra lumen and intraprostatic reflux lumen play an important rolebetween re -repetitions.Initially, in the first group, this indicator was the NIH-CPSI scale, 2 (1-3) points in the second group-2 (1-3) points and 2 (1-3) points.
The severity of urinary tract disorders did not differ statistically significantly between groups (p = 0.937).The test groups were homogeneous relative to LUTS.There was no difference between the groups of the urine log.It is reasonable to say that Lut is associated with prostate disease, not the functional disorders of the bladder or water balance.
According to Uroflowmetry, the maximum urinary tract speed was 13.3 (11.8-14.2) ml/s in the second group - 13.2 (12.1-14.0) ml/s and 13.0 (11.8-14.6) ml/s in the control group.There was no statistically significant difference between groups in this indicator (p = 0.996).The remaining urine was the first, the second and the control groups 23.0 (20-26), 23 (18-25) and 20 (16.5-24) ml.Patient groups were not different in this indicator (p = 0.175).
It can be stated that in patients with chronic prostatitis, highlights of reservoir and bladder evacuation functions have not been observed in chronic prostatitis, but existing Luts allow you to suspect the source of pathological symptoms exactly at the prostate urethra.
The subjective perception of patients with chronic prostatitis symptoms is also of great importance.Different uncomfortable feelings that have different severity that are prone to repetition, often unpredictable, and significantly disrupt men's usual lifestyle.This influences not only their mood but also their social activities.This is the reason why the study of quality of life, which depends on the severity of the disease, its decline and consequences, also serves as a criterion for the effectiveness of treatment.
Before the treatment was prescribed, the red root tincture, plus 1 teaspoon per day in a group of 1 teaspoon, the questionnaire was evaluated at 6 (5-9) points in the group, which received the tincture three times a day - 8 (6-9) and in the control group.There was no statistically significant difference between groups (p = 0.22).
The total score of the NIH-CPSI scale in the first group is 22 (19-25), the second group-23 (19-25) and the control-22 (18-25) (p = 0.801).Thus, groups were homogeneous not only on the symptomatic scale of chronic prostatitis, but also for each component, but also for each component.All patients responded on the copulative function scale of men (MCF).In the first group, the indicator was 31 (23-41) points, the second - 34 (27-39) points, the third - 34 (26-37).The effect of chronic prostatitis on erection function remains the subject of the study.
In all three groups, the value range is quite wide.This indicates that it responds to a person's individual degree to his symptoms and disorders.At the same time, the distribution of patients with chronic prostatitis, which are placed in groups with different erection functions, were not different before treatment (p = 0.967).Thus, at the beginning of the study, three groups of chronic prostatitis can be formed that were homogeneous at the age, type and severity of clinical symptoms, which influenced the quality of life.At the same time, the reservoir disorders and the evacuation functions of the bladder were ruled out.
After 30 days of treatment, the symptoms were evaluated in the formed groups.The tincture of the forgotten Pennyweed root in a group of patients with a teaspoon of 1 day three times a day, according to the control questionnaire, was observed by 51%of the frequency and severity of pain and discomfort.When taking 2 teaspoons of tincture three times a day, a reduction in the severity of the symptoms was observed by 55%.
In the control group, the abnormal symptoms decreased by 37%.The differences between the three patients were statistically significant (p = 0.029).However, no statistically significant differences were found between the first and second groups.Thus, it can be a clinically significant effect with a minimum dose of the drug.In addition, there were statistically significant differences in reducing pathological symptoms when the tincture of the forgotten kopeck roots were tincture compared to control.
According to the questionnaire, urinary tract performance was improved in patients with chronic prostatitis, but the differences were neither statistically significant, nor among groups that had a tincture of Pennywort's roots in different doses and compared to the control group.
There were no statistically significant differences in the analysis of the data of the urine log after treatment.According to the results of control uroflowmetry, the increase in the maximum urinary flow rate was observed in all groups, which changed from 5 to 12%.The remainder of the urine decreased by 4-6%in patients treated with various doses and herbal medicines.The differences between groups were not statistically significant.
This fact can be explained by the relatively short time of use and the lack of components in the red root plus tincture, which would be similar to α-adrenergic blockers and 5α-reductase inhibitors.The main active ingredient of the drug is the compounds of bioflavonoids, which have various effects, primarily antioxidant and anti -inflammatory effects.
According to the control study, the improvement of quality of life was observed after 30 days of treatment.In the first group, this figure changed by 55%, in the second-59%and 39%in the control group.The differences in the dynamics of the dynamics of the forgotten kopeck and the control group were statistically significant (p = 0.008).
It should be noted that groups that received tincture in different portions were not significantly different in the dynamics of quality of life.Analysis of changes in quality of life confirms the adaptogenic effects of the components of the forgotten Kopes and Knotweed herbal preparation.The total score of NIH-CPSI in all three groups after 30 days of treatment.In the first group, the second decreased by 50%-52%and third in the third-29%.At the same time, the same tendency was observed as analyzing other indicators.
The difference was statistically significant among patients who received the roots of the forgotten Kopeck and patients with the control group and found no difference between groups who received medication in different doses.
All three patient groups showed the same increase in the full score of the ICF questionnaire (p = 0.455).Changes in the indicator in all groups did not exceed 10%.There was no statistically significant difference between groups.
The improvement of the copulation function can be associated primarily by decreasing the abnormal symptoms of the prostate gland, the decrease of LUTs, adaptogenic properties and better microcirculation.The condition of the prostate gland when using herbal preparations is interesting.This is presented by analysis of the results of a repeated examination of prostate secretion.
If patient groups were not initially different in the presence and number of leukocytes in prostate secretion (p = 0.528), after 30 days of treatment in all groups, the severity of the inflammatory process was reduced.In groups of the forgotten Pennyweed root tincture, the statistically significant (p = 0.028) decrease was observed in the number of leukocytes compared to the control group.Changing the dosage of the drug did not affect the dynamics of the reduction of leukocytes.
According to a study by prostate secretion, a significant decrease in the severity of the inflammatory process and the improvement of the functional state of the prostate gland were determined.
Various herbal medicines contain a unique bioflavonoid that has different activity.Obviously, the combination of audience and knotweed rhizomes and roots contains bioflavonoids that are active in prostate tissue against the effects of oxidative stress.This can be assumed based on the result of the effectiveness of the drug and the lack of dose -dependent differences.However, further research should be confirmed.
Conclusion
Among the methods of treating prostatitis, the use of herbal preparations takes a significant space.The efficiency of the drug group is confirmed by clinical experience.According to modern ideas about the active principle, modern ideas about herbal remedies also allow a new approach to herb to a new approach to the herb.
The efficiency of plant bioflavonoids is confirmed by the theory of oxidative stress that the products of oxidation of non -controlled free radicals have a detrimental effect on the cell and cause dysfunction of many organs and systems.
With the above, herbal medicine seems to be the most effective in the treatment of chronic prostatitis, both most effective in the treatment of chronic prostatitis, using the tincture of herbs with pronounced anti -inflammatory and antioxidant effects.